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Publications

Aydin Y, Coin I. Biochemical Insights into Structure and Function of Arrestins. FEBS J (2021). 

Işbilir A, Serfling R, Möller J, Thomas R, De Faveri C, Zabel U, Scarselli M, Beck-Sickinger AG, Bock A, Coin I, Lohse MJ, Annibale P. Determination of G-protein-coupled receptor oligomerization by molecular brightness analyses in single cells. Nat Protoc (2021). 

Kaiser A, Coin I. Capturing Peptide-GPCR Interactions and Their Dynamics. Molecules (2020). 

Böttke T, Ernicke S, Serfling R, Ihling C, Burda E, Gurevich VV, Sinz A, Coin I. Exploring GPCR-arrestin interfaces with genetically encoded crosslinkers. EMBO Rep (2020). 

Clark LJ, Krieger J, White AD, Bondarenko V, Lei S, Fang F, Lee JY, Doruker P, Böttke T, Jean-Alphonse F, Tang P, Gardella TJ, Xiao K, Sutkeviciute I, Coin I, Bahar I, Vilardaga JP. Allosteric interactions in the parathyroid hormone GPCR-arrestin complex formation. Nat Chem Biol (2020).

Serfling R, Seidel L, Bock A, Lohse MJ, Annibale P and Coin I. Quantitative single-residue bioorthogonal labeling of G protein-coupled receptors in live cells. ACS Chem Bio (2019).

Seidel L, Zarzycka B, Katritch V, Coin I. Exploring Pairwise Chemical Crosslinking To Study Peptide-Receptor Interactions. Chembiochem (2019).

Coin I. Application of non-canonical crosslinking amino acids to study protein-protein interactions in live cells. Curr Opin Chem Biol (2018).

Serfling R, Seidel L, Böttke T, Coin I. Optimizing the Genetic Incorporation of Chemical Probes into GPCRs for Photo-crosslinking Mapping and Bioorthogonal Chemistry in Live Mammalian Cells. J Vis Exp (2018).

Seidel L, Coin I. Mapping of Protein Interfaces in Live Cells Using Genetically Encoded Crosslinkers. Methods Mol Biol (2018).

Serfling R, Lorenz C, Etzel M, Schicht G, Böttke T, Mörl M, Coin I. Designer tRNAs for efficient incorporation of non-canonical amino acids by the pyrrolysine system in mammalian cells. Nucleic Acids Res (2018).

Seidel L, Zarzycka B, Zaidi SA, Katritch V, Coin I. Structural insight into the activation of a class B G-protein-coupled receptor by peptide hormones in live human cells. Elife (2017).

Coin I, Katritch V, Sun T, Xiang Z, Siu FY, Beyermann M, Stevens RC, Wang L. Genetically encoded chemical probes in cells reveal the binding path of urocortin-I to CRF class B GPCR. Cell (2013).

Kang JY, Kawaguchi D, Coin I, Xiang Z, O'Leary DD, Slesinger PA, Wang L. In vivo expression of a light-activatable potassium channel using unnatural amino acids. Neuron (2013).

Xiang Z, Ren H, Hu YS, Coin I, Wei J, Cang H, Wang L. Adding an unnatural covalent bond to proteins through proximity-enhanced bioreactivity. Nat Methods (2013).

Parrish AR, She X, Xiang Z, Coin I, Shen Z, Briggs SP, Dillin A, Wang L. Expanding the genetic code of Caenorhabditis elegans using bacterial aminoacyl-tRNA synthetase/tRNA pairs. ACS Chem Biol (2012).

Westendorf C, Schmidt A, Coin I, Furkert J, Ridelis I, Zampatis D, Rutz C, Wiesner B, Rosenthal W, Beyermann M, Schülein R. Inhibition of biosynthesis of human endothelin B receptor by the cyclodepsipeptide cotransin. J Biol Chem (2011).

Coin I, Perrin MH, Vale WW, Wang L. Photo-cross-linkers incorporated into G-protein-coupled receptors in mammalian cells: a ligand comparison. Angew Chem Int Ed Engl (2011).

Coin I. The depsipeptide method for solid-phase synthesis of difficult peptides. J Pept Sci (2010). 

Coin I, Schmieder P, Bienert M, Beyermann M. The depsipeptide technique for the solid phase peptide synthesis: from stepwise assembly to segment condensation. Adv Exp Med Biol (2009).

Coin I, Beerbaum M, Schmieder P, Bienert M, Beyermann M. Solid-phase synthesis of a cyclodepsipeptide: cotransin. Org Lett (2008).

Coin I, Beyermann M, Bienert M. Solid-phase peptide synthesis: from standard procedures to the synthesis of difficult sequences. Nat Protoc (2007).

Coin I, Schmieder P, Bienert M, Beyermann M. The depsipeptide technique applied to peptide segment condensation: scope and limitations. J Pept Sci (2008).  

Stella L, Burattini M, Mazzuca C, Palleschi A, Venanzi M, Coin I, Peggion C, Toniolo C, Pispisa B. Alamethicin interaction with lipid membranes: a spectroscopic study on synthetic analogues. Chem Biodivers (2007).

Coin I, Dölling R, Krause E, Bienert M, Beyermann M, Sferdean CD, Carpino LA. Depsipeptide methodology for solid-phase peptide synthesis: circumventing side reactions and development of an automated technique via depsidipeptide units. J Org Chem (2006).

Peggion C, Coin I, Toniolo C. Total synthesis in solution of alamethicin F50/5 by an easily tunable segment condensation approach. Biopolymers (2004).

Address

Institute of Biochemistry
Brüderstraße 34
D-04103 Leipzig

Contacts

Email: info@coin-lab.de                 
Phone: +49 341 97-36996              
Fax: +49 341 97-36909